To improve the performance of autonomous vehicle navigation system,this paper proposes a car Global Positioning System/Dead Reckoning(GPS/DR) integrated navigation system utilizing car non-holonomic constrains and odometer speed information to assist strap-down Inertial Navigation System (INS) when GPS signal is blocked. The Kalman filtering dynamic model for the proposed car GPS/DR integrated navigation system is deduced. The simulation on computer and car experiment are performed to verify the proposed method. The results show that proposed method provides high position accuracy,meeting the requirement of some vehicle autonomous navigation. When GPS signal is blocked for 90 s,the maximized position error is 20 m in the turn and straight line area.