A mixed feed-forward control method based on T-S fuzzy model combined with pulse jet and pressure fluctuation feed-forward is proposed to decrease the timing disturbance on the negative pressure of wind dust removal pipeline caused by pulse jet in flat bag dedusting system. The proposed method is applied in the practical production environments with concentrated wind power processes in Shandong and other provinces. The operation results indicate that, it can effectively weaken the disturbance on pipeline negative pressure caused by pulse jet, and simplify the control with good stability and robustness.