高灵敏度太赫兹超材料对于生物组织切片的研究

Terahertz metamaterials with high sensitivity for biological tissue slices study

摘要:

太赫兹波在生物医学领域具有非电离、无标签、实时等优点，因此在该领域具有巨大的发展潜力。为了解决介电常数相近的生物组织之间的区分问题，设计并制造了一种具有Fano共振特性的超材料，并进行太赫兹反射成像实验。模拟和实验结果显示，在0.82 THz下，该超材料的反射灵敏度达到132 GHz/RIU。该超材料不仅可以提高标准成像分辨率板的对比度，还可以将肌肉组织和脂肪组织之间对比度提高约7.5%。这些结果表明，该超材料能够显著提高生物组织切片图像的对比度，为今后太赫兹应用于临床组织样本奠定了实验和理论基础。

Abstract:

Terahertz(THz) wave has great development potential in biomedical science due to its nonionizing, labelless and real-time characteristics. To distinguish biological tissues with similar permittivity, a metamaterial with Fano resonance is designed and fabricated for THz reflection imaging. The simulation and experimental results show that the reflection sensitivity of the metamaterial is 132 GHz/RIU at 0.82 THz. The metamaterial not only enhances the contrast of imaging resolution plate, but also improves the contrast between the muscle and the fat tissues by approximately 7.5%, therefore, it can improve the contrast of biological tissue slice images. This work has established an experimental and theoretical foundation for future terahertz applications in clinical tissue samples.