基于太赫兹超材料对不同脑功能区识别研究

Research on the identification of different brain functional regions based on terahertz metamaterials

摘要:

神经系统疾病的精准诊断和个性化治疗对改善患者预后至关重要。太赫兹(THz)超材料因其独特的光谱特性，成为研究脑组织不同功能区的重要工具。采用THz超材料对大脑组织切片进行检测，重点分析杏仁核、运动皮层、听皮层、海马体、下丘脑和丘脑等关键功能区。通过测量各区域的谐振频率和振幅变化，验证THz超材料在识别不同脑区的能力。各脑功能区的谐振频率和振幅均发生显著变化，其中海马体谐振峰的共振幅度ΔA变化最大，从7.62%上升至20.35%；运动皮层、听皮层和杏仁核的共振频率偏移显著，偏移量Δf达到(369±4.4) GHz，下丘脑区域偏移23.77 GHz。这些差异与各脑区的生物物理特性密切相关。研究表明，THz超材料能够有效区分脑功能区的频谱特性。

Abstract:

Precise diagnosis and personalized treatment of neurological diseases are crucial for improving patient outcomes. Terahertz(THz) metamaterials, due to their unique spectral properties, have become essential tools for studying different functional areas of brain tissue. THz metamaterials are employed to detect brain tissue sections, with a focus on analyzing key functional areas such as the amygdala, motor cortex, auditory cortex, hippocampus, hypothalamus, and thalamus. By measuring the resonant frequencies and amplitude changes in each area, the ability of THz metamaterials to identify different brain regions is verified. The resonant frequencies and amplitudes in each brain functional area have undergone significant changes. Among them, the hippocampus shows the largest change in resonance peak amplitude(ΔA), increasing from 7.62% to 20.35%. The motor cortex, auditory cortex, and amygdala show significant resonance frequency shifts, with a shift amount(Δf) reaching (369±4.4) GHz, while the hypothalamus shows a shift of 23.77 GHz. These differences are closely related to the biophysical properties of each brain area. The study indicates that THz metamaterials can effectively distinguish the spectral characteristics of brain functional areas.